Family: Thomas Speke, Sir / Anne Berkeley, Lady (F5449)
m. 1510
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 | John Speke of Whitelackington (1468-1524)
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 | Alice Arundell, Lady  (1475-1519)
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| Richard Berkeley (1465-1513)
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| Elizabeth Coningsby (1483-1546)
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| John Berkeley (1495-1545)  |
| Thomas Speke, Sir (1508-1551)
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| Anne Berkeley, Lady (1504-1564)
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| Elizabeth Speke (1540- ) |