Family: Thomas Appleton / Lady Mary Jane Isacke (F12682)
m. 23 Oct 1564
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 | William Appleton (1513-1563)
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 | Rose Sexton (1517-1578)
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| Edward Isaac (1510-1573)
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| Margery Whetehill (1515-1572)
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| Thomas Appleton (1536-1603)
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| Lady Mary Jane Isacke (1552-1613)
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| Honorable Samuel Appleton (1586-1670)  |