| # | Children | Name | Born | Died | Father | Mother |
|---|
| 1 | | | b. 2 Feb 1778 | d. Yes, date unknown | William Algernon Alston, Senator | Mary Ashe |
| 2 | Yes | | b. 10 Nov 1779 | d. 19 Sep 1816 | William Algernon Alston, Senator | Mary Ashe |
| 3 | | | b. 25 Jun 1782 | d. 16 Sep 1860 | William Algernon Alston, Senator | Mary Ashe |
| 4 | | | b. 1783 | d. 1831 | William Algernon Alston, Senator | Mary Ashe |
| 5 | | | b. 1784 | d. 26 Nov 1817 | William Algernon Alston, Senator | Mary Ashe |
| 6 | Yes | | b. 20 Feb 1794 | d. 29 Apr 1861 | William Algernon Alston, Senator | Mary Ashe |
| 7 | Yes | | b. 27 Aug 1796 | d. 6 Jan 1881 | William Algernon Alston, Senator | Mary Ashe |
| 8 | | | b. 3 Dec 1797 | d. 10 Sep 1818 | William Algernon Alston, Senator | Mary Ashe |
| 9 | | | b. 9 Jun 1799 | d. 3 Mar 1867 | William Algernon Alston, Senator | Mary Ashe |
| 10 | | | b. Abt 1801 | d. Jul 1802 | William Algernon Alston, Senator | Mary Ashe |
| 11 | Yes | | b. 17 Jun 1803 | d. 4 Oct 1884 | William Algernon Alston, Senator | Mary Ashe |
| 12 | Yes | | b. 7 Feb 1792 | d. 25 Jan 1853 | William Algernon Alston, Senator | Mary Brewton Motte |
1756 - 1839 (82 years)